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Transduction of Host Genes

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Bacteriophage genomes can pick up cellular genes and deliver them to new cells (a process known as transduction). For example, occasional mistakes in excision of the lambda prophage from its host chromosome after induction result in production of unusual progeny phages that have lost some of their own DNA but have acquired the bacterial DNA adjacent to the prophage. The acute transforming retroviruses also arise via capture of genes in the vicinity of their integration as proviruses (Volume II, Chapter 6). These cancer-inducing cellular genes are then transduced along with viral genes during subsequent infection.

Principles of Virology

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