Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 53

Francis Crick conceptualized the central dogma for flow of information from the DNA genome in all living cells:

DNA → mRNA → protein

As intracellular parasites that depend on the host cell’s translational machinery for protein production, all viruses must direct the synthesis of mRNAs. But viral genomes comprise both DNA and RNA in a variety of conformations. Appreciation of the essential role of the translational machinery in virus reproduction inspired David Baltimore, in 1971, to devise a classification scheme for viruses, based on the steps that would be required to produce mRNA from their diverse genomes (Fig. 1.12).