Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 135

FFP is plasma separated from WB and placed at −18°C or lower within 8 hours of collection [24]. Fresh plasma may be frozen by placing it in a liquid freezing bath composed of ethanol and dry ice, or between blocks of dry ice, or in a mechanical or a blast freezer. The unit of FFP has a volume of about 200–250 mL and contains all of the coagulation factors present in fresh blood. FFP can also be produced as a by‐product of plateletpheresis, and this may result in a unit of FFP with a volume of about 500 mL, often called “jumbo” units of FFP. These can be stored or separated into two separate products. The electrolyte composition of FFP is that of freshly collected blood and the anticoagulant solution. FFP is not considered to contain red cells, and so is usually administered without regard to Rh type. However, there have been occasional rare reports suggesting that units of FFP contain a small amount of red cell stroma that can cause immunization to red cells [56]. Because it contains ABO antibodies, the plasma must be compatible with the recipient’s red cells. The number of leukocytes in FFP depends on the centrifugation procedures used for preparation.