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The leukocyte content of the platelet concentrates is an important issue (see Chapters 10, 11, and 16). The conditions used to centrifuge WB influence the leukocyte content of the platelet concentrate, but most platelet concentrates contain 10⁸ or more leukocytes. Filters are available that remove most of the leukocytes in the platelet concentrate. The filters can be used at the bedside, or preferably before the platelets are stored. All platelets should be leukodepleted.

Filters are available for leukodepletion of platelets, as well as red cells. This is necessary if it is hoped to prevent alloimmunization or cytomegalovirus transmission in patients receiving platelet transfusion [53]. The platelet filters result in a loss of about 20–25% of the platelets and have a rate of failure in achieving fewer than 5 × 10⁶ leukocytes of about 5–7% [53].