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Most donors are 30–50 years old, with an average age between 33 and 38 years [4, 9, 11]. The age range of donors shifted during the 1980s and 1990s from only about 2–3% of donors older than 60 years in the 1970s to 10% of donors older than 60 years and 4% older than 65 years in the 1990s [9]. This apparent “aging” of the donor population could reflect a shift in the population age in general; however, during the past few years, blood bank professionals have recognized that blood donation is safe for older individuals, and donor age limits have therefore been extended to attract older donors (see Chapter 4). During the past few years, recruitment of college and high school students has been emphasized, and they now account for about 8% of donations [12]. Younger donors are more likely than repeat donors to experience a reaction [12, 13]. Because donors who experience a reaction are less likely to return [12–15], strategies to minimize reactions in young and first‐time donors are being developed (see Chapter 4). Donors most likely to return are those aged 16 and 17 years and older than 50 years, males, blood group O donors (probably because they are sought by the blood centers), and those without any initial adverse reaction [15, 16].