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Cephaloceles

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occupy a very different position. The condition is by no means confined to man, and many instances are recorded as occurring throughout the animal kingdom. Norsa Gurrieri,[6] for instance, records a case occurring in the embryo of Mus decumanus vel albinus. The same writer insists that the developmental error involves bones of either cartilaginous or membranous origin, and that the atrophic condition of the bone is the primary cause and the ectopia of the brain a secondary result.

Lyssenkow,[7] after careful investigation of tumours removed by operation and after death, found scattered nerve-fibres, fat-cells, striated muscle and vessels—the products, therefore, of both ectoderm and mesoderm. He also observed the frequent occurrence of an intimate union or fusion between the cephalocele and the overlying integument, and, in consequence, the theory was formulated that the greater number of cephaloceles were in reality cephalomata or true teratoid tumours.

It would appear, therefore, that a cephalocele results from the incomplete cutting off of the neural canal in the head region of the embryo from the overlying epiblast, with consequent fusion between the primary neural tube (from which the brain is developed) with the primordial mesoblastic membranous cranium (from which the membranes are developed), and with the overlying epiblastic layer (from which the epidermal portion of the scalp is developed). In consequence of this localized fusion of layers, the outer dermic coat (from which the membranous skull is developed) fails to form. Bony defects therefore exist through which brain-matter protrudes, the projecting portion often being intimately attached to the skin, and containing not only epiblastic elements, but also mesoblastic tissue from irregular occlusion of the same. The mesoblastic involvement is proved by the presence in the tumour of muscle tissue, vessels, &c.

The Surgery of the Skull and Brain

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