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Treatment involves reducing toxin absorption (by induction of emesis and/or gastric lavage and administration of activated charcoal and an osmotic cathartic) (Table 4.1), methocarbamol to control the muscle tremors and AEMs (see Table 4.1 and Chapters 12 and 24) and supportive care (intravenous fluid therapy, convective whole body cooling and, in severely affected animals, intubation and ventilation). Emesis should be induced in asymptomatic animals that present within 15–30 min after suspected or confirmed ingestion of mouldy food or non-corrosive waste material (Barker et al., 2013). Administration of activated charcoal should be repeated over 1–3 days due to entero-hepatic recirculation of mycotoxins. Seizures may not respond to diazepam administration and it has been suggested that poor or no response to diazepam is suggestive of mycotoxicosis (Barker et al., 2013). If there is inadequate response after the first administration of diazepam, alternative AEMs such as levetiracetam, phenobarbital, propofol and ketamine (see Table 4.1 and Chapter 24) should be used.