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Treatment includes decontamination (by induction of emesis and/or gastric lavage, administration of activated charcoal), AEMs (see Table 4.1 and Chapters 12 and 24) and supportive care including intravenous fluid therapy and convective whole body cooling. Cyproheptadine, a serotonin antagonist, has been used at 1.1 mg/kg, PO or rectally, every 1 to 4 h until signs resolve. Rectal administration may be preferred when severe vomiting or recent administration of activated charcoal make the oral route unfeasible (Gwaltney-Brant et al., 2000).