Читать книгу Constitutional Oncogenetics - Noureddine Boukhatem - Страница 23

The BRCA1 gene codes for a 220 kDa (1,863 amino acids) nuclear polypeptide. The BRCA1 protein has been implicated in various cellular processes, including repair of DNA damage and regulation of the transcription cycle, chromatin remodeling and ubiquitination. More recently, it has been shown to play a role in splicing and mediating estrogenic metabolites.