Читать книгу Constitutional Oncogenetics - Noureddine Boukhatem - Страница 28

The BRCA1 gene associated RING domain 1 (BARD1) encodes a protein that interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the two most conserved regions of BRCA1: the N-terminal RING pattern and the C-terminal BRCT domain. The formation of a stable complex between the BRCA1/BARD1 proteins may be an essential aspect of the tumor suppressor function of BRCA1.