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I would like to thank several people who influenced me during the writing of this book. I am fortunate and honoured to have made acquaintance with Professor A.W.F. Edwards (University of Cambridge) and thank him for his suggestions and reprints. I appreciate the replies to my questions from Professor P. Dixon (University of Alberta) and Dr Scott Glover (University of London). This book would have been difficult to complete without the support of my loving wife Annah Adero. Finally, this book is dedicated to the College of Medicine at Alfaisal University in Riyadh.