Читать книгу Immunology - Richard Coico - Страница 2
Table of Contents
Оглавление1 COVER
7 PREFACE AND ACKNOWLEDGMENTS TO THE EIGHTH EDITION
8 HOW TO USE YOUR TEXTBOOK FEATURES CONTAINED WITHIN YOUR TEXTBOOK
10 1 OVERVIEW OF THE IMMUNE SYSTEM INTRODUCTION INNATE AND ADAPTIVE IMMUNITY HEMATOPOIESIS AND THE DEVELOPMENT OF THE IMMUNE SYSTEM CLONAL SELECTION THEORY ACTIVE, PASSIVE, AND ADOPTIVE IMMUNIZATION HUMORAL AND CELLULAR IMMUNITY IMMUNE BALANCE GENERATION OF DIVERSITY IN THE IMMUNE RESPONSE BENEFITS OF IMMUNOLOGY DAMAGING EFFECTS OF THE IMMUNE RESPONSE THE FUTURE OF IMMUNOLOGY THE SHORT COURSE BEGINS HERE REFERENCES AND BIBLIOGRAPHY
11 2 CELLS AND TISSUES OF THE IMMUNE SYSTEM INTRODUCTION THE LYMPHATIC SYSTEM MAJOR HEMATOPOIETIC CELLS LYMPHOCYTE MIGRATION AND RECIRCULATION THE FATE OF ANTIGEN AFTER PENETRATION REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
12 3 CELLS OF THE INNATE IMMUNITY INTRODUCTION PHYSICAL AND CHEMICAL BARRIERS OF INNATE IMMUNITY CELLS OF THE INNATE IMMUNE SYSTEM PATTERN RECOGNITION: A MAJOR FEATURE OF INNATE IMMUNE RESPONSES COMPLEMENT THE INFLAMMATORY RESPONSE REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
13 4 COMPLEMENT INTRODUCTION OVERVIEW OF COMPLEMENT ACTIVATION REGULATION OF COMPLEMENT ACTIVITY BIOLOGICAL ACTIVITIES OF COMPLEMENT COMPLEMENT DEFICIENCIES REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
14 5 IMMUNOGENS AND ANTIGENS INTRODUCTION REQUIREMENTS FOR IMMUNOGENICITY PRIMARY AND SECONDARY RESPONSES ANTIGENICITY AND ANTIGEN‐BINDING SITE EPITOPES RECOGNIZED BY B CELLS AND T CELLS MAJOR CLASSES OF ANTIGENS BINDING OF ANTIGEN WITH ANTIGEN‐SPECIFIC ANTIBODIES OR T CELLS CROSS‐REACTIVITY ADJUVANTS REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
15 6 ANTIBODY STRUCTURE, FUNCTION, AND INTERACTIONS WITH ANTIGEN INTRODUCTION ISOLATION AND CHARACTERIZATION OF IMMUNOGLOBULINS STRUCTURE OF LIGHT AND HEAVY CHAINS DOMAINS HINGE REGION VARIABLE REGION IMMUNOGLOBULIN VARIANTS STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGG STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGM STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGA STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGD STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGE KINETICS OF THE ANTIBODY RESPONSE FOLLOWING IMMUNIZATION THE IMMUNOGLOBULIN SUPERFAMILY ANTIGEN–ANTIBODY INTERACTIONS SECONDARY INTERACTIONS BETWEEN ANTIBODY AND ANTIGEN REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
16 7 ORGANIZATION AND EXPRESSION OF LYMPHOCYTE ANTIGEN RECEPTOR GENES INTRODUCTION A BRIEF REVIEW OF GENE STRUCTURE AND GENE EXPRESSION B‐CELL ANTIGEN‐SPECIFIC RECEPTORS AND RECEPTOR GENES GENETIC EVENTS IN SYNTHESIS OF Ig CHAINS IMMUNOGLOBULIN CLASS SWITCHING GENERATION OF ANTIBODY DIVERSITY ROLE OF ACTIVATION-INDUCED CYTIDINE DEAMINASE IN GENERATING ANTIBODY DIVERSITY T‐CELL ANTIGEN‐SPECIFIC RECEPTORS AND RECEPTOR GENES GENES CODING FOR T‐CELL RECEPTORS GENERATION OF T‐CELL RECEPTOR DIVERSITY REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
17 8 THE MAJOR HISTOCOMPATIBILITY COMPLEX AND ANTIGEN PRESENTATION INTRODUCTION HOW THE MHC GOT ITS NAME MHC ROLE IN ANTIGEN PRESENTATION DIFFERENT MHC MOLECULES ARE EXPRESSED BY DISTINCT HOST CELLS AND INTERACT WITH DIFFERENT SETS OF T CELLS VARIABILITY OF MHC CLASS I AND MHC CLASS II MOLECULES STRUCTURE OF MHC CLASS I AND CLASS II MOLECULES ANTIGEN PROCESSING AND PRESENTATION: HOW MHC MOLECULES BIND PEPTIDES AND CREATE LIGANDS THAT INTERACT WITH T CELLS OTHER TYPES OF ANTIGEN THAT ACTIVATE T‐CELL RESPONSES GENES OF THE HLA REGION NOMENCLATURE OF POLYMORPHIC MHC MOLECULES REGULATION OF EXPRESSION OF MHC GENES MHC IN OTHER SPECIES DIVERSITY OF MHC MOLECULES: MHC ASSOCIATION WITH RESISTANCE AND SUSCEPTIBILITY TO DISEASE REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
18 9 B‐CELL DEVELOPMENT AND ACTIVATION INTRODUCTION DEVELOPMENT OF B LYMPHOCYTES GENETICS OF IMMUNOGLOBULIN GENE REARRANGEMENTS NEGATIVE SELECTION AND THE DEVELOPMENT OF CENTRAL TOLERANCE B‐CELL ACTIVATION B‐CELL MEMBRANE PROTEINS REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
19 10 T‐CELL DEVELOPMENT AND ACTIVATION INTRODUCTION THE ANTIGEN‐SPECIFIC T‐CELL RECEPTOR GENES CODING FOR T‐CELL RECEPTORS GENERATION OF T‐CELL RECEPTOR DIVERSITY T‐CELL DIFFERENTIATION IN THE THYMUS ACTIVATION AND FUNCTION OF T CELLS A TWO‐SIGNAL MODEL FOR THE ACTIVATION OF T CELLS DENDRITIC CELLS ARE THE KEY APC FOR NAÏVE T CELLS ACTIVATION OF CD4+ T CELLS CD4+ T‐CELL FUNCTION ACTIVATION AND FUNCTION OF CD8+ T CELLS MEMORY T CELLS FUNCTION OF OTHER SUBSETS OF T CELLS REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
20 11 CYTOKINES INTRODUCTION THE HISTORY OF CYTOKINES GENERAL PROPERTIES OF CYTOKINES FUNCTIONAL CATEGORIES OF CYTOKINES CYTOKINE RECEPTORS CYTOKINE RECEPTOR‐MEDIATED SIGNAL TRANSDUCTION ROLE OF CYTOKINES AND CYTOKINE RECEPTORS IN DISEASE THERAPEUTIC EXPLOITATION OF CYTOKINES AND CYTOKINE RECEPTORS REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
21 12 TOLERANCE AND AUTOIMMUNITY INTRODUCTION CENTRAL TOLERANCE PERIPHERAL TOLERANCE ORAL TOLERANCE IMMUNE PRIVILEGE AUTOIMMUNITY VERSUS AUTOIMMUNE DISEASE AUTOIMMUNE DISEASES REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
22 13 HYPERSENSITIVITY: TYPE I INTRODUCTION GENERAL CHARACTERISTICS OF ALLERGIC REACTIONS SENSITIZATION PHASE ACTIVATION PHASE EFFECTOR PHASE CLINICAL ASPECTS OF ALLERGIC REACTIONS CLINICAL TESTS FOR ALLERGIES AND CLINICAL INTERVENTION THE PROTECTIVE ROLE OF IgE REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
23 14 HYPERSENSITIVITY: TYPES II AND III INTRODUCTION TYPE II HYPERSENSITIVITY EXAMPLES OF TYPE II HYPERSENSITIVITY REACTIONS TYPE III HYPERSENSITIVITY REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
24 15 HYPERSENSITIVITY: TYPE IV INTRODUCTION GENERAL CHARACTERISTICS AND PATHOPHYSIOLOGY OF DTH EXAMPLES OF DTH TREATMENT OF DTH REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
25 16 IMMUNODEFICIENCY DISORDERS AND NEOPLASIAS OF THE LYMPHOID SYSTEM INTRODUCTION IMMUNODEFICIENCY SYNDROMES ACQUIRED IMMUNODEFICIENCY SYNDROME NEOPLASMS OF LYMPHOID SYSTEM REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
26 17 TRANSPLANTATION INTRODUCTION RELATIONSHIP BETWEEN DONOR AND RECIPIENT IMMUNE MECHANISMS ARE RESPONSIBLE FOR ALLOGRAFT REJECTION CATEGORIES OF ALLOGRAFT REJECTION ROLE OF MHC MOLECULES IN ALLOGRAFT REJECTION ROLE OF T‐CELL LINEAGES AND CYTOKINES IN ALLOGRAFT REJECTION LABORATORY TESTS USED IN TISSUE TYPING PROLONGATION OF ALLOGRAFT SURVIVAL: IMMUNOSUPPRESSIVE THERAPY HEMATOPOIETIC STEM CELL TRANSPLANTATION GRAFT‐VERSUS‐HOST DISEASE XENOGENEIC TRANSPLANTATION THE FETUS: A TOLERATED ALLOGRAFT REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
27 18 TUMOR IMMUNOLOGY INTRODUCTION TUMOR ANTIGENS TUMOR IMMUNITY THE IMMUNOSUPPRESSIVE ACTIONS OF TUMOR CELLS IMMUNOTHERAPY REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
28 19 RESISTANCE AND IMMUNIZATION TO INFECTIOUS DISEASES INTRODUCTION HOST DEFENSE AGAINST THE VARIOUS CLASSES OF MICROBIAL PATHOGENS MECHANISMS BY WHICH PATHOGENS EVADE THE IMMUNE RESPONSE PRINCIPLES OF IMMUNIZATION OBJECTIVES OF IMMUNIZATION ACTIVE IMMUNIZATIONS BASIC MECHANISMS OF PROTECTION VACCINE PRECAUTIONS RECENT APPROACHES TO PRODUCTION OF VACCINES PASSIVE IMMUNIZATION REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
29 20 EXPERIMENTAL SYSTEMS AND METHODS INTRODUCTION IMMUNOASSAYS IMMUNOFLUORESCENCE FLOW CYTOMETRY IMMUNOABSORPTION AND IMMUNOADSORPTION CELLULAR ASSAYS CELL CULTURE EXPERIMENTAL ANIMAL MODELS INBRED STRAINS TRANSGENIC MICE AND GENE TARGETING ANALYSIS OF GENE EXPRESSION REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
30 GLOSSARY
31 APPENDIX: Partial List of CD Antigens
32 INDEX
