Читать книгу Immunology - Richard Coico - Страница 69

RIG‐I‐like receptors (RLRs) constitute a family of three cytoplasmic RNA helicases that are critical for host antiviral responses. They sense double‐stranded RNA, a replication intermediate for RNA viruses, leading to production of type I interferons (interferon‐α and interferon‐β) in infected cells.

Figure 3.6. Binding of pathogen‐associated molecular patterns (PAMPs) to the core form of an inflammasome. Binding of PAMPs to leucine‐rich repeats (LRRs) on cytoplasmic inflammasomes causes the core form to bind to an adaptor protein and caspase‐1. This is followed by oligomerization of the inflammasome, which enables it to catalyze the conversion of inactive IL‐1β to active IL‐1β