Читать книгу Essential Endocrinology and Diabetes - Richard I. G. Holt - Страница 54

 To understand the principles of hormone–receptor interaction

 To know the different classes of hormone receptors and how they functionTyrosine kinase receptors and their signalling pathwaysG‐protein–coupled receptors and their signalling pathwaysNuclear receptors and how they regulate gene expression

 To appreciate the role of transcription factors that are important in endocrine development and function

 To appreciate how abnormalities in hormone receptors or their downstream signalling can cause endocrinopathy

This chapter describes the key events that occur within the cell following stimulation by hormone

Hormones act by binding to receptors. There are two superfamilies of hormone receptor: the cell‐surface receptors and the nuclear receptors, named according to their site of action. Both classes display characteristic features (Figure 3.1 and Box 3.1).