Читать книгу Essential Endocrinology and Diabetes - Richard I. G. Holt - Страница 62

Intrinsic tyrosine kinase receptors auto‐phosphorylate upon binding of the appropriate hormone. This group includes the receptors for insulin, epidermal growth factor (EGF), fibroblast growth factor (FGF) and insulin‐like growth factor I ( IGF‐I). EGF and FGF receptors exist as monomers that dimerize upon hormone binding. The dimerization activates tyrosine phosphorylation. Those for insulin and IGF‐I exist in their unoccupied state as preformed dimers. The signalling pathways for all these receptors are heavily involved in cell growth and proliferation.