Читать книгу Essential Endocrinology and Diabetes - Richard I. G. Holt - Страница 68

The commonest subset of cell‐surface receptors (>140 members) couples to G‐proteins at the inner surface of the cell membrane. It has been recently discovered by high‐resolution imaging that this receptor‐G‐protein contact occurs at specific hotspots around the cell membrane linked to the cell’s internal cytoskeleton. The contacts last for approximately one second and lead to the generation of intracellular second messengers such as adenosine‐3′,5′‐cyclic monophosphate (cyclic AMP or cAMP), diacylglycerol (DAG) and inositol triphosphate (IP₃). In addition to hormones, GPCRs also exist for glutamate, thrombin, odorants and the visual transduction of light.