Читать книгу Fundamentals of Analytical Toxicology - Robin Whelpton - Страница 50

The analysis of faeces is rarely performed in clinical chemistry, but sometimes drug and possibly metabolite analysis may be required in pharmacokinetic and metabolism studies. Analyses may also be requested if, for example, drug leakage from ingested packets of drug is suspected. Unlike plasma, urine, and other fluid samples, faeces are not homogeneous, and thus it is often necessary to analyze the whole sample or homogenize the whole sample and prove that the fraction taken for analysis is representative of the whole. It may take more than a day after dosage before a drug or a drug metabolite appears in faeces. The stability of some drugs in meconium has been assessed (Wu et al., 2017).