Читать книгу Dental Management of Sleep Disorders - Ronald Attanasio - Страница 44

This substance (hormone) impacts arousal and wakefulness. Cortisol is released by the adrenal glands and is associated with stress. It plays a role in maintaining alertness and is increased in the early morning hours to promote wakefulness. Being increased with stress it may be associated with depression and insomnia. In patients with OSA cortisol release associated with awakening is reduced and with adequate management of the OSA the levels improve [39]. The release of cortisol is associated with the HPA axis (hypothalamic–pituitary–adrenal axis); however, this is somewhat controversial as it relates to sleep.