Читать книгу Musculoskeletal Disorders - Sean Gallagher - Страница 41

Repetitive work tasks are known risk factors for causing work‐related musculoskeletal chronic muscle pain and fatigue (Bongers et al., 2006; Larsson et al., 2007; Sjøgaard et al., 2000). In normal skeletal muscle, highly repetitive and high force work tasks can independently induce muscle inflammation and fibrosis, concomitant with muscle pain and weakness, with greater pathology when the two risk factors are combined (Barbe, Gallagher, Massicotte, et al., 2013b; Barbe, Gallagher, & Popoff, 2013a; Fisher et al., 2015; Hilliard et al., 2020). Exposure‐dependent fibrogenic changes have been observed in an operant rat model of work (repetitive reaching and grasping a varied load levels), with longer duration and higher repetitive and force demand tasks inducing greater tissue fibrosis than shorter or easier tasks, with evidence of inflammation at earlier time points and more fibrosis at later time points after inflammation has resolved (Barbe, Gallagher, Massicotte, et al., 2013b; Barbe, Gallagher, & Popoff, 2013a).