Читать книгу Principles of Dentoalveolar Extractions - Seth Delpachitra - Страница 15

This typically starts around day three and lasts for up to three weeks. The proliferative phase relies on the formation of granulation tissue and type III collagen, mediated by fibroblasts; wound contraction starts due to the action of myofibroblasts. Angiogenesis takes place as new capillaries are formed to provide blood and nutrients in order to help the wound heal. A number of growth factors, including vascular endothelial growth factor (VEGF), are also involved. At the wound edges, epithelial cells proliferate and begin to grow over the granulation tissue scaffold that has formed. Bone healing starts to take place as osteoprogenitor cells arrive, differentiating into osteoblasts, which begin depositing an osteoid matrix. Note that any systemic conditions or medications which prevent or suppress components of angiogenesis or inflammation may delay or prolong healing.