Читать книгу Cell Biology - Stephen R. Bolsover - Страница 2

1  COVER

2  TITLE PAGE

3  COPYRIGHT PAGE

4  PREFACE

5  ACKNOWLEDGMENTS

6  ABOUT THE COMPANION WEBSITE

7  SECTION 1: THE STRUCTURE OF THE CELL 1 A LOOK AT CELLS AND TISSUES ONLY TWO TYPES OF CELL VIRUSES ORIGIN OF EUKARYOTIC CELLS CELL SPECIALIZATION IN ANIMALS STEM CELLS AND TISSUE REPLACEMENT THE CELL WALL MICROSCOPES REVEAL CELL STRUCTURE FLUORESCENCE MICROSCOPY FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 2 MEMBRANES AND ORGANELLES BASIC PROPERTIES OF CELL MEMBRANES ORGANELLES BOUNDED BY DOUBLE‐MEMBRANE ENVELOPES ORGANELLES BOUNDED BY SINGLE MEMBRANES THE CONNECTED CELL FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION

8  SECTION 2: THE MOLECULAR BIOLOGY OF THE CELL 3 DNA STRUCTURE AND THE GENETIC CODE THE STRUCTURE OF DNA DNA AS THE GENETIC MATERIAL PACKAGING OF DNA MOLECULES INTO CHROMOSOMES THE GENETIC CODE FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 4 DNA AS A DATA STORAGE MEDIUM DNA REPLICATION PROTEINS OPEN UP THE DNA DOUBLE HELIX DURING REPLICATION BIOCHEMISTRY OF DNA REPLICATION DNA REPAIR AFTER REPLICATION GENE STRUCTURE AND ORGANIZATION IN EUKARYOTES GENE NOMENCLATURE FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 5 TRANSCRIPTION AND THE CONTROLOF GENE EXPRESSION STRUCTURE OF RNA RNA POLYMERASE GENE NOTATION BACTERIAL RNA SYNTHESIS CONTROL OF BACTERIAL GENE EXPRESSION EUKARYOTIC RNA SYNTHESIS CONTROL OF EUKARYOTIC GENE EXPRESSION NONCODING RNAs AND THE CONTROL OF EUKARYOTIC GENE EXPRESSION FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 6 MANUFACTURING PROTEIN ATTACHMENT OF AN AMINO ACID TO ITS tRNA THE RIBOSOME BACTERIAL PROTEIN SYNTHESIS EUKARYOTIC PROTEIN SYNTHESIS IS A LITTLE MORE COMPLEX ANTIBIOTICS AND PROTEIN SYNTHESIS PROTEIN DESTRUCTION FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 7 PROTEIN STRUCTURE NAMING PROTEINS POLYMERS OF AMINO ACIDS OTHER AMINO ACIDS ARE FOUND IN NATURE THE THREE‐DIMENSIONAL STRUCTURES OF PROTEINS LEVELS OF COMPLEXITY PROSTHETIC GROUPS THE PRIMARY STRUCTURE CONTAINS ALL THE INFORMATION NECESSARY TO SPECIFY HIGHER‐LEVEL STRUCTURES PROTEIN–PROTEIN INTERACTIONS UNDERLIE ALL OF CELL BIOLOGY FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 8 RECOMBINANT DNA TECHNOLOGYAND GENETIC ENGINEERING DNA CLONING CREATING THE CLONE USES OF DNA CLONES “OMICS” IDENTIFYING THE GENE RESPONSIBLE FOR A DISEASE REVERSE GENETICS TRANSGENIC AND KNOCKOUT MICE RNA INTERFERENCE (RNAi) CRISPR/CAS9 ETHICS OF DNA TESTING FOR INHERITED DISEASE FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION

9  SECTION 3: CELL COMMUNICATION 9 CARRIERS, CHANNELS, AND VOLTAGES CARRIERS THE POTASSIUM GRADIENT AND THE RESTING VOLTAGE THE ACTION POTENTIAL FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 10 SIGNALING THROUGH IONS CALCIUM AS A SIGNALING ION PROPAGATING THE SIGNAL RAPID COMMUNICATION: FROM NEURONS TO THEIR TARGETS REVIEW QUESTIONS THOUGHT QUESTION 11 SIGNALING THROUGH ENZYMES G PROTEIN‐COUPLED RECEPTORS AND SECOND MESSENGERS RECEPTOR TYROSINE KINASES AND THE MAP KINASE CASCADE CYTOKINE RECEPTORS SIGNALING THROUGH PROTEOLYSIS INTRACELLULAR RECEPTORS CROSSTALK – SIGNALING PATHWAYS OR SIGNALING WEBS? SIGNALING IN THE CONTROL OF MUSCLE BLOOD SUPPLY FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION

10  SECTION 4: THE MECHANICS OF THE CELL 12 INTRACELLULAR TRAFFICKING PRINCIPLES OF PROTEIN TRANSPORT TRAFFICKING TO THE ENDOPLASMIC RETICULUM AND PLASMA MEMBRANE TRAFFICKING TO THE LYSOSOME TRAFFICKING TO AND FROM THE NUCLEUS TRAFFICKING TO OTHER ORGANELLES FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 13 CELLULAR SCAFFOLDING MICROTUBULES FUNCTIONS OF MICROTUBULES MICROFILAMENTS FUNCTIONS OF MICROFILAMENTS INTERMEDIATE FILAMENTS FUNCTIONS OF INTERMEDIATE FILAMENTS FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION 14 CONTROLLING CELL NUMBER M‐PHASE CONTROL OF THE CELL CYCLE MEIOSIS AND FERTILIZATION CELL DEATH FURTHER READING REVIEW QUESTIONS THOUGHT QUESTION

11  SECTION 5: CASE STUDY 15 CASE STUDY CYSTIC FIBROSIS IS A SEVERE GENETIC DISEASE THE FUNDAMENTAL LESION IN CYSTIC FIBROSIS LIES IN CHLORIDE TRANSPORT CLONING THE CFTR GENE THE CFTR GENE CODES FOR A CHLORIDE ION CHANNEL REPLACING OR REPAIRING THE GENE TAILORING TREATMENT TO THE PATIENT'S LESION NEW TREATMENTS FOR CF DIAGNOSTIC TESTS FOR CF CONCLUSION FURTHER READING REVIEW QUESTIONS THOUGHT QUESTIONS

12  ANSWERS TO REVIEW QUESTIONSANSWERS TO REVIEW QUESTIONS

13  GLOSSARY

14  INDEX

15  END USER LICENSE AGREEMENT