Читать книгу Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting - Tamilvanan Shunmugaperumal - Страница 24

SYED NAZRIN RUHINA RAHMAN* AND TAMILVANAN SHUNMUGAPERUMAL

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India

1  2.1. Introduction

2  2.2. FDA‐approved oils, emulsifiers, and auxiliary or miscellaneous excipients 2.2.1. Issues related to oil selection to make the o/w nanosized emulsions for medical application 2.2.2. Issues related to emulsifiers selection to stabilize the o/w nanosized emulsions for medical application 2.2.3. Importance of charge‐stabilized nanosized emulsions 2.2.4. Importance of neutral‐charged (sterically‐stabilized) nanosized emulsions 2.2.5. Advantages of nanosized emulsions stabilized by mixed or multicomponent emulsifier molecules 2.2.6. ‘Stealth’ property of nanosized emulsions: in vitro demonstrations 2.2.7. Advantages of stabilizers in nanosized emulsions 2.2.8. Miscellaneous additives

3  2.3. Current and near future direction 2.3.1. Colloidal particles‐stabilized emulsions

4  2.4 Lipophilic API incorporation pattern into nanosized emulsions 2.4.1. Extemporaneous API Addition 2.4.2. De Novo Emulsion Preparation 2.4.3. Interfacial Incorporation Approach 2.4.4. Incorporation of Antibodies, DNA Protein, Oligonucleotide, or Heat Labile Molecules

5  2.5 QbD approach to optimize emulsion 2.5.1. Case study for optimizing systematically a formula to make o/w nanosized Emulsions

6  2.6. Conclusion References