Читать книгу Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting - Tamilvanan Shunmugaperumal - Страница 38

Cohen et al. (1996), when looking for a new galenic presentation form for amphotericin B with better ocular tolerance over the commercially available Fungizone^® eye drops, incorporated the API directly into the preformed 20% emulsion, Intralipid^®. However, after addition of the solid API particles or API solution, several physical changes such as phase separation, precipitation, or creaming may occur thus limiting such practices in o/w nanosized emulsion preparations. Therefore, ocular active lipophilic agents are not normally incorporated into the emulsions by this extemporaneous addition method.