Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 184

In the chain of thousands of nucleotides that make up an mRNA, the ribosome must bind and initiate translation at the correct site. If the ribosome starts working at the wrong position, the protein will have the wrong N-terminal amino acids and/or the mRNA will be translated out of frame and all of the amino acids will be wrong. Hence, mRNAs have sequences called translational initiation regions (TIRs) or ribosome-binding sites (RBSs) that flag the correct first codon for the ribosome. In spite of extensive research, it is still not possible to predict with 100% accuracy whether a sequence is a TIR. However, some general features of TIRs are known.