Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 79

Much has been learned about the molecular events occurring during the initiation of replication. Some of this information has a bearing on how the initiation of chromosome replication is regulated and serves as a model for the interaction of proteins and DNA.

Two types of functions are involved in the initiation of chromosome replication. One consists of the sites or sequences on DNA at which proteins act to initiate replication. These are called cis-acting sites. The prefix cis means “on this side of,” and these sites act only on the same DNA. The proteins involved in initiation of replication are examples of trans-acting functions. The prefix trans means “on the other side of,” and these functions can act on any DNA in the same cell, not just the DNA from which they were made. The concepts of cis- and trans-acting properties are common in molecular genetics, and these references are used throughout this book.