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RNA Priming of Initiation

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As described above, RNA primers are continuously needed during the DNA replication process. The complex that travels along the chromosome laying down RNA primers is called the primosome and contains DnaB and DnaG primase. The RNA polymerase that synthesizes most of the RNA molecules, including mRNA, in the cell (see chapter 2) is needed to initiate rounds of replication; however, transcription from RNA polymerase in this context from adjacent genes is involved in controlling the separation of the strands of DNA in the oriC region. DnaG primase is responsible for laying down RNA primers for DNA synthesis after replication is initiated at oriC.

Snyder and Champness Molecular Genetics of Bacteria

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