Читать книгу General system theory of aging. Special role of the immune system - V. I. Dontsov - Страница 15

System analysis allows us to consider aging from several global points of view, thereby revealing the fundamental, general, global mechanisms or types of aging, as a reflection of fundamentally unidirectional common processes of aging.

Although the specific mechanisms of aging for different types of tissues and organisms can be quite different, all of them can be grouped into 2 groups that are essentially homogeneous according to the global mechanism, resulting from the global cause of aging – the law of increasing entropy in some incompletely open systems, and also from counteraction by biological systems – processes of regulation of growth and development of a biosystem.

Existing theories of aging focus on several hundred specific mechanisms of aging. However, attentive analysis of these mechanisms and essential modeling of the aging process ((Dontsov, 1990; 2011; 2017; Gompertz, 1825; Hayflick, 2007; Murphy, Partridge, 2008; Vern et al., 2009: van Leeuwen et al., 2010; Walker, 2011; Kirkwood, Melov, 2011; Masoro, Austad, 2011; Rando, Chang, 2012), as well as consideration of the aging phenomenon given in previous publications, allow us to group these mechanisms into a small number of classes – general aging mechanisms and in general can only be theoretically reduced to stochastic and regulatory types of aging, while for biological systems the stochastic type appears as a probabilistic death of non-renewable elements, as well as a “contamination” of the system by external intoxes ikantami and internal metabolites.

Thus, if there is one common cause of aging, there are 2 types of aging and 3 main, fundamental mechanisms of aging.