Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 88

Results of an in vitro study with Caco2 cells show that terfenadine is a substrate of Pgp. The authors suggest that inhibition of intestinal Pgp efflux transport (e.g. by ketoconazole) may contribute to a higher plasma concentration [199]. This suggestion is not yet substantiated by clinical findings.