Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 97

The current information suggests that environmental and genetic factors that could enhance the formation of reactive metabolites (e.g. inducers of CYP1A1 and myeloperoxidase), reduction of cellular GSH, and inflammatory insults are likely risk factors for trovafloxacin hepatotoxicity.