Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 96

While there are no reports on the role of transporters on hepatic uptake and efflux, it has been reported that trovafloxacin could bioaccumulate in cultured human polymorphonuclear leukocytes (PMNs), human peritoneal macrophages, and tissue‐cultured epithelial cells (McCoy cells), albeit in a nonsaturable manner and was enhanced at 4 °C, thereby eliminating the involvement of uptake transporters [243].