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Understanding the Difference between Osteoarthritis and Rheumatoid Arthritis

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RA and OA have two things in common: namely joint pain and damage to certain joint structures, such as the cartilage and the bone. Other than that, they’re about as different as night and day. Table 3-1 outlines the differences between RA and osteoarthritis.

TABLE 3-1 Rheumatoid Arthritis Compared to Osteoarthritis

Rheumatoid Arthritis Osteoarthritis
Joint inflammation and swelling are prominent symptoms. Joint inflammation and swelling are less common.
Usually begins between the ages of 25 to 50, but can also strike children. Usually begins after the age of 40. Rarely strikes children.
Settles in a majority of joints, especially fingers, wrists, shoulders, knees, and elbows. Affects the weight-bearing joints primarily (for example, knees, hips, and spine).
Affects joints symmetrically (for example, both wrists). Affects isolated joints or one joint at a time.
Morning stiffness lasts more than 30 minutes. Brief periods of morning stiffness.
Often causes systemic symptoms, such as fatigue, fever, weight loss, and general malaise. In severe cases, they can attack organs outside the joints. Does not cause systemic symptoms.
Arthritis For Dummies

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