Читать книгу Neurology - Charles H. Clarke - Страница 89

Transient receptor potential (TRP) channels are related to voltage‐gated potassium channels. Several members are sensitive to temperature and chemical ligands and have a role in sensory transduction. Mutations of TRPV4 can cause abnormalities of peripheral nerve development and function. Mutations of TRPA1 – an ion channel best known as a sensor for pain and itch – can cause a paroxysmal pain disorder. Acquired changes may also explain some aspects of neuropathic pain.