Читать книгу Neurology - Charles H. Clarke - Страница 95

Several autoimmune disorders affect ion channels. Antibodies recognise extracellular epitopes, for example AChRs, P/Q‐type calcium channels, glycine and NMDA receptors. Aquaporin 4 (see antibodies in Devic’s, Chapter 11) is a transmembrane protein that permits the flow of water between glial cells. The way that an ion channel is affected is similar in both an acquired and hereditary channelopathy – as one might expect because each ion channel has a limited repertoire. More antibody‐channel interactions are likely to be discovered and to be of significance.