Читать книгу Neurology - Charles H. Clarke - Страница 94

GABA_A receptors are structurally homologous to nicotinic receptors but are permeable to chloride ions instead of sodium and potassium. They mediate fast inhibitory transmission and are the sites of action of benzodiazepines and other anti‐epileptic, and anxiolytic drugs. Loss‐of‐function mutations have been reported in epilepsy.

Glycine receptors also homologous to GABA_A mediate fast inhibition in the spinal cord and brainstem. AD or AR loss‐of‐function mutations of GLRA1 cause familial hyperekplexia.

Glutamate receptors mutations have been described in schizophrenia, and in rolandic epilepsy.