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The topical medication is applied three times a day – after breakfast, after lunch and before going to bed. Patients will be advised to brush their teeth, gargle and dry the area/s of the lesion/s before each application. Emphasis will be made to use a mirror to see where the medication is to be applied. Patients will be asked to note each application in a patient diary, to monitor compliance. They are instructed not to eat, drink or smoke for 30 minutes after the application.