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Example 3.11 Protocol ENSG5 (1990): Comparison of high dose rapid schedule with conventional schedule chemotherapy for stage 4 neuroblastoma over the age of 1 year 12. MODIFICATION OF THERAPY DUE TO TOXICITY

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The aim of the protocol is to administer the maximally tolerated chemotherapy in both arms. There are no specifically determined toxicity modifications but if significant toxicity occurs please contact study co‐ordinators.

Randomised Clinical Trials

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