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PHARMACOLOGY

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•All diuretics cause hypokalemia Except the K+ sparing diuretics.

•All H1 blockers cause drowsiness EXCEPT for Seldane.

•All drugs cross the placenta EXCEPT for heparin.

•All third generation cephalosporins are used parenterally EXCEPT for Cefixime (orally)

•Drug of choice for all nematode infections (round, pin, hook and whipworm) is Mebendazole, EXCEPT for two "T" nematodes (Threadworm and Trichinella) that are acted upon by a "T" drug--Thiabendazole.

•All diuretics cause hypokalemia EXCEPT SAT (Spironolactone, Amiloride, and Triamterene)

•Clomipramine resembles tricyclic antidepressants in structure but acts like SSRI’s (Fluoxetine, Sertraline, Paroxetine and Fluvoxamine)

•All MAO inhibitors are Type A except for selegiline.

•Bleomycin is the oddball anticancer drug.

•The anticancer drug that is most noticeable for causing gout is mercaptopurine.

•The antipsychotic drug that is most noticeable for causing Pigmentary retinopathy is Thioridazine.

•The two drugs that cause Steven Johnson Syndrome are Sulfonamides and penicillin.

•The three drugs that are noticeable for causing gingival hyperplasia are: Phenytoin, nifedipine and cyclosporine.

•The only antiviral used in Parkinson’s dz. is amantadine.

•Penicillins act on all Bacteroides except fragilis.

•The nerve that is uniquely damaged by aminoglycosides is CN VIII.

•All aminoglycosides are administered parenterally EXCEPT for neomycin.

•No tetracycline can enter a non-inflamed brain EXCEPT Minocycline.

•The two anticancer drugs that have cardiotoxicity are doxorubicin and daunorubicin.

•The two anticancer drugs that cause pulmonary toxicity are bleomycin and methotrexate.

•The only neurotoxic anticancer is vincristine.

•The only phototoxic anticancer is 5-flurouracil.

•The only ototoxic anticancer is cisplatin.

•The two anticancers that have NO bone toxicity are bleomycin and vincristine.

•The two anticancers that readily enter into the CNS are carmustine and lomustine.

•The most common cause of folic acid deficiency among the anticancers is methotrexate.

•The only anticancer that causes hemorrhagic cystitis is Cyclophosphamide.

•The unique antidepressant that is an SSRI but at times act like a MAOIs is trazodone.

•The least sedative TCA is Desipramine.

•The teratogenic antidepressant is lithium.

•The anticonvulsant that is only used for petit mal seizures is ethosuximide.

•The only two drugs that cause dissociative anesthesia are halopridol and ketamine.

•The unique antibiotic with the broadest spectrum—acting on both gram-positive and negative bugs is impipenem.

•The most toxic antibiotics are aminoglycosides.

•The penicillin most notorious for causing acute interstitial nephritis is methicillin.

•The two penicillins that are notorious for sodium-loading are ticarcillin and carbencillin.

•The three cephalosporins that are notorious for causing disulfiram reaction are: Cefoperazone, Cefamandole and Cefotetan.

•The tetracycline that has the best CSF penetrating ability is minocycline.

•The unique tetracycline used in the treatment of SIADH is demeclocycline.

•The only tetracycline that can be administered to a renally compromised patient is Doxycycline.

•The antibiotic family that uniquely damages tendons is quinolones.

•The only non-fluorinated quinolone is nalidixic acid.

•The only sulfa medication used in ulcerative colitis is sulfasalazine.

•The top two antibiotics causing photosensitivity are tetracycline and sulfonamides.

Primary Care for COMLEX Level 1

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