Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 14

 The variability in the relationship between dose and response is a measure of the sensitivity of a patient to a drug. This has two components: dose–concentration (pharmacokinetics) and concentration–effect (pharmacodynamics)

 Pharmacokinetics describes the processes of drug absorption, distribution, metabolism and excretion

 Clinical pharmacology seeks to explore the factors that underlie variability in pharmacodynamics and pharmacokinetics for the optimization of drug therapy in individual patients

More recently, the development of genomics and proteomics has provided additional insights and opportunities for drug development with new and more specific targets. Such knowledge will replace the concept of one drug and/or one dose fitting all.