Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 17

Enzymes, like receptors, are protein macromolecules with which substrates interact to produce activation or inhibition. Drugs in common clinical use which exert their effect through enzyme action generally do so by inhibition, for example:

1 Aspirin inhibits platelet cyclo‐oxygenase

2 Ramipril inhibits angiotensin‐converting enzyme

Drug receptor antagonists and enzyme inhibitors can act as competitive, reversible antagonists or as non‐competitive, irreversible antagonists. Effects of competitive antagonists can be overcome by increasing the dose of endogenous or exogenous agonists, while effects of irreversible antagonists cannot usually be overcome, resulting in a longer duration of the effect.