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The commonest complication of glucose control in the ICU is hypoglycemia which is defined as blood glucose less than 80 mg/dL. The association between mortality and glucose level is 'J‐shaped' meaning that there is increased mortality at both extremes making it important to avoid hypoglycemia.

 Blood glucose 90–120: hold insulin infusion and repeat blood glucose in 1 hour.

 Blood glucose 71–89: hold insulin infusion and repeat glucose in 30 minutes.

 Blood glucose 51–70: give 12.5 g of 50% dextrose and repeat glucose in 15 minutes.

 Blood glucose <50: give 25 g of 50% dextrose then confirm reading with arterial blood if possible and repeat glucose in 15 minutes.