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Immune tolerance is the ability of the immune system to identify and respond to foreign or non‐self‐antigens, while aborting or controlling potentially deleterious responses to autoantigens [1]. Despite genetic variability within the population and substantial differences in environmental exposures that shape an individual's immune repertoire, the vast majority of people maintain immune tolerance to self‐antigens. As a result, autoimmune diseases are rare, even among persons with genetic susceptibility [2]. In contrast, rare monogenetic defects predictably result in the development of autoimmune diseases in early life [1]. Broadly, immune tolerance is divided into two categories: natural and inducible tolerance. In addition, natural tolerance has been subclassified as either central or peripheral, based the anatomic site of development.