Читать книгу Autoimmune Liver Disease - Группа авторов - Страница 64

MicroRNAs(miRNAs) function epigenetically as posttranscriptional and posttranslational regulators of gene expression [17]. miRNAs and TFs regulate each other's expression in feedback loops: TFs are negatively regulated by miRNAs, while miRNAs are positively regulated by TFs. Compelling evidence indicates that miRNAs control the activation state of innate macrophages and DCs, activation of T cells, apoptotic elimination of activated T and B cells, and the critical balance between iTregs and Th17 cells in sites of inflammation. To date multiple miRNAs have been implicated in the immunopathogenesis of autoimmune diseases, including AILDs.