Читать книгу Autoimmune Liver Disease - Группа авторов - Страница 52

B cells develop tolerance to self‐antigens in the bone marrow by both B‐cell receptor (BCR) editing and clonal deletion of autoreactive B cells [9]. BCR editing results from the induction of VDJ recombinase and rearrangements which lead to production of new immunoglobulin‐edited light chains that modify the specificity of BCRs to prevent recognition of autoantigens.