Читать книгу Methodologies in Amine Synthesis - Группа авторов - Страница 28

Nitrogen radicals are powerful intermediates in synthetic chemistry. Their ability to undergo selective H‐atom transfer reactions represents a valuable tool for the assembly and functionalization of organic molecules. Although the large body of work and examples are already available, several challenges are still unsolved. For example, the ability to control in a general sense the stereochemical outcome of these transformations is currently not possible but would be highly desirable. Furthermore, these processes have rarely been used in large‐scale settings, especially at an industrial level, so further work would be required to identify reaction protocols that can be translated into process development. Finally, an area where continuous development and application is required involves the use of these strategies for the late‐stage modification of complex and bioactive materials. The ability to selectively target specific and unactivated sp³‐centers, where a functionality can be introduced, would represent a powerful tool in order to better explore chemical space around lead molecules.