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Pediatric HCT survivors are at risk for depression, fatigue, pain, social withdrawal, educational problems, vocational problems including unemployment and dependent living (see Table 8.1). They are less likely to report risky health behaviors (alcohol and smoking). Among autologous recipients younger age and current chronic pan were independently associated with greater depression and fatigue and among allogeneic recipients, cGVHD severity, being female, and with current pain were associated with both depression and fatigue [112].