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Restrictive lung disease is frequently observed 3 to 6 months after HSCT in patients conditioned with TBI and receiving an allogeneic HSCT but, in most cases, it is not symptomatic. Restrictive disease is often stable and, in fact, may resolve, partially or completely, within 2 years of HSCT. However, some patients do develop severe late restrictive defects and may eventually die from respiratory failure [31,34].