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On 26 December 2000, EPA launched the Voluntary Children's Chemical Evaluation Program (VCCEP) Pilot by asking companies that manufactured or imported one or more of the 23 chemicals selected for the program to volunteer to sponsor their chemicals and provide information on health effects, exposure, risk, and data needs. Thirty‐five companies and 10 consortia responded, volunteering to sponsor 20 chemicals.

Under the VCCEP Pilot, EPA collects three tiers of increasingly detailed information on a chemical from its sponsor. EPA asked companies to volunteer to sponsor their chemical(s) for Tier 1. After completing the evaluation of some Tier 1 chemical assessments, EPA determines if additional data is needed. EPA gives sponsors the opportunity to commit to one tier at a time. Companies are only asked to sponsor particular tiers when EPA believes the data to be provided are necessary to understand the chemical's potential impact on children. During their sponsorship, companies collect and/or develop health effects and exposure information on their chemical(s) and integrate that information in a risk assessment. A “data needs assessment,” also developed by the sponsor, discusses the need for additional data, which can be provided as part of the next tier of information to fully characterize the risks the chemical may pose to children.