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The effects of chronic stress can be reduced via pharmaceutical agents such as sleep medications, anxiolytics, antidepressants, and β-blockers as well as by drugs that reduce oxidative stress and inflammation such as statins, insulin resistance treatments, and analgesics [20]. However, there are counterarguments against pharmaceutical remediation, especially as they pertain to the widespread systemic dysregulations inherent in AL. In the original formulation of the allostasis concept, Sterling and Eyer [5] argued that medical practices based on homeostatic models were in danger of iatrogenesis (ailments brought forth by a healer) and polypharmacy as treatment problems can arise when correcting one parameter causes dysregulation among other systems. Ultimately, the challenge is to develop pharmaceutical treatments with minimal side effects and inadvertent recalibrations of subsidiary systems. Because AL represents multisystemic, subclinical dysregulations predating the emergence of clinical outcomes, treatment options targeting the aforementioned psychological, behavioral, cognitive, and social domains could be complimentary and indeed facilitative towards improving efficacy and compliance to low-dose pharmacotherapy aimed at proactive prevention instead of reactive prescription.