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The brain is central to allostasis and AL. Stress hormones bypass the blood-brain barrier to bind to three key receptor-dense regions: the prefrontal cortex, the amygdala, and the hippocampus. Chronic production of cortisol is believed to be neurotoxic, leading to frontal lobe malfunctioning, amygdaloidal hypertrophy, and hippocampal atrophy associated with region-specific cognitive impairments and emotional dysregulations throughout the life cycle [6]. Furthermore, individual differences in constitutional (e.g. genetics, development, and experience), behavioral (e.g. coping and health habits), and historical (e.g. trauma/abuse, major life events, and stressful environments) factors also modulate an individual’s sensitivity to chronic stress that can further damage the brain and body. Of critical importance is the timing and duration at which major stressors and/or traumas are experienced, as this will profoundly affect neurological development that, in turn, can exacerbate the inherent vulnerabilities conferred onto individuals.