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High methanogen concentrations were found in patients with diverticulosis [29]. This suggests that the diverticula may provide an optimal environment for the growth of methanogens. It is possible that the diverticula may provide a sheltered niche where the slow-growing methanogens are not swept away and where symbiotic relationships with H₂-producing organisms may occur. Since CH₄ production occurs mainly in the left colon, H₂ produced in the left colon may be rapidly converted to CH₄, possibly resulting in reduced flatus.

Table 1. Direction of diffusion of gas between the lumen and mucosal blood